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Taking too high a dose can make you feel so unwell that you stop the medication altogether, leading to a cycle of weight regain

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The mechanisms are complementary rather than competitiveGLP-1 reduces energy in, while MOTS-c and 5-Amino-1MQ increase energy out

Quick Answer: Co-prescribing Rybelsus (semaglutide) and Januvia (sitagliptin) is generally not recommended in UK clinical practice due to overlapping incretin-based mechanisms that provide limited additional glycaemic benefit